Last update
9/16/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 6 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**
Top Medical Research Studies
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
8
We investigated how quercetin can help protect kidneys from damage caused by diabetes in rats. Our study involved forty male Wistar rats divided into different groups to compare the effects of quercetin treatment before and after diabetes was induced.
We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
Read More
Most Useful Reviews
9
Beneficial for allergies
1 people found this helpful
Excellent product! I’ve appreciated the quality of Quercetin from a trusted supplier. The medium-sized capsules are easy to swallow. I take it during spring when tree pollen triggers my allergies; thanks to this supplement, I experienced no allergic reactions last year. I also use it during colds and buy it regularly. I highly recommend it!
Read More
9
Stable lung condition
1 people found this helpful
I have been taking it for two consecutive years to protect my respiratory system due to nodules in my lungs. My lung condition is now very good; the nodules remain stable, and I no longer experience significant symptoms. I will continue to take it to manage inflammation.
Read More
9
Product satisfaction
Прекрасно! The product was well packed, and I definitely noticed the effect! I will order more! Delivery was quick as well.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
9
We explored how Sendeng-4, a traditional Mongolian medicine, can ease rheumatoid arthritis (RA). By using advanced methods to analyze its active components, we identified key phytochemicals and mapped their effects on biological pathways.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
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9
Quercetin liposomes aid diabetes therapy
We observed that a new form of quercetin, delivered in lipid nanoparticles, can help alleviate diabetes symptoms in rats. This improved bioavailable quercetin significantly reduced blood glucose levels and lowered pancreatic oxidative stress and inflammation.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
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8
Quercetin shows promise for RA treatment
We examined the active components in the Additive Sishen Decoction (ASSD), a traditional Chinese medicine for rheumatoid arthritis (RA). Our findings revealed that key ingredients—quercetin, kaempferol, and luteolin—play a significant role in reducing inflammation through specific pathways.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Beneficial for allergies
1 people found this helpful
Excellent product! I’ve appreciated the quality of Quercetin from a trusted supplier. The medium-sized capsules are easy to swallow. I take it during spring when tree pollen triggers my allergies; thanks to this supplement, I experienced no allergic reactions last year. I also use it during colds and buy it regularly. I highly recommend it!
Read More
9
Stable lung condition
1 people found this helpful
I have been taking it for two consecutive years to protect my respiratory system due to nodules in my lungs. My lung condition is now very good; the nodules remain stable, and I no longer experience significant symptoms. I will continue to take it to manage inflammation.
Read More
9
Product satisfaction
Прекрасно! The product was well packed, and I definitely noticed the effect! I will order more! Delivery was quick as well.
Read More
6
Relieved allergy symptoms
3 people found this helpful
Wonderful! This is my favourite antiviral remedy. Previously, I took vitamin C, zinc, and echinacea when I was ill, but now I find that Quercetin with zinc suffices. My father developed an allergy from his medication but couldn’t stop taking them. After starting Quercetin, his allergy symptoms have diminished. I also give it to my child when they feel unwell by mixing half a capsule with food or water.
Read More
9
Highly effective treatment
1 people found this helpful
Excellent! Very effective. Would like to order more.
Read More
Frequently Asked Questions
9
Beneficial for allergies
1 people found this helpful
Excellent product! I’ve appreciated the quality of Quercetin from a trusted supplier. The medium-sized capsules are easy to swallow. I take it during spring when tree pollen triggers my allergies; thanks to this supplement, I experienced no allergic reactions last year. I also use it during colds and buy it regularly. I highly recommend it!
9
Stable lung condition
1 people found this helpful
I have been taking it for two consecutive years to protect my respiratory system due to nodules in my lungs. My lung condition is now very good; the nodules remain stable, and I no longer experience significant symptoms. I will continue to take it to manage inflammation.
7.5
Viral treatment aid
I ordered it to support my treatment for viral infections and colds. I take it with zinc for better absorption, one capsule per day. When I have a fever, I take zinc and quercetin three times daily, along with omega, NAC, and vitamin C. This protocol, recommended by many doctors, truly helps me.
6
Relieved allergy symptoms
3 people found this helpful
Wonderful! This is my favourite antiviral remedy. Previously, I took vitamin C, zinc, and echinacea when I was ill, but now I find that Quercetin with zinc suffices. My father developed an allergy from his medication but couldn’t stop taking them. After starting Quercetin, his allergy symptoms have diminished. I also give it to my child when they feel unwell by mixing half a capsule with food or water.
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
8
We explored the potential of quercetin-enhanced micelles specifically designed to target the inflammatory environment of rheumatoid arthritis (RA). By using a unique synthesis method, these micelles were made to respond to the specific enzymes found in the diseased tissue.
Our findings indicated that the smart micelles not only showcased strong anti-inflammatory and cartilage-protective properties but also effectively targeted activated macrophages. Overall, this innovative approach offers a promising new avenue for RA treatment, presenting an opportunity to manage this challenging condition with improved efficacy and fewer side effects.
Our findings indicated that the smart micelles not only showcased strong anti-inflammatory and cartilage-protective properties but also effectively targeted activated macrophages. Overall, this innovative approach offers a promising new avenue for RA treatment, presenting an opportunity to manage this challenging condition with improved efficacy and fewer side effects.
References
- Ren J, Liu Z, Qi X, Meng X, Guo L, et al. Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification. Drug Des Devel Ther. 2025;19:405. 10.2147/DDDT.S489323
- Yang J, Yang H, Wang F, Dai Y, Deng Y, et al. Bioinformatics identification based on causal association inference using multi-omics reveals the underlying mechanism of Gui-Zhi-Shao-Yao-Zhi-Mu decoction in modulating rheumatoid arthritis. Phytomedicine. 2025;136:156332. 10.1016/j.phymed.2024.156332
- Zhendong Y, Changjun C, Haocheng H, Qibin L, Dailing C, et al. Regulation of macrophage polarization and pyroptosis by 4-methylcatechol alleviates collagen-induced arthritis via Nrf2/HO-1 and NF-κB/NLRP3 signaling pathways. Int Immunopharmacol. 2025;146:113855. 10.1016/j.intimp.2024.113855
- Priya PS, Murugan R, Srileka R, Ramya Ranjan Nayak SP, Margesan T, et al. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Microb Pathog. 2024;197:107086. 10.1016/j.micpath.2024.107086
- Xiong F, Shen K, Long D, Zhou S, Ruan P, et al. Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway. Immun Ageing. 2024;21:69. 10.1186/s12979-024-00474-9
- Karnam S, Jindal AB, Paul AT. Quality by design-based optimization of teriflunomide and quercetin combinational topical transferosomes for the treatment of rheumatoid arthritis. Int J Pharm. 2024;666:124829. 10.1016/j.ijpharm.2024.124829
- Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Mol Med. 2024;30:170. 10.1186/s10020-024-00929-1
- Wu Z, Hu J, Li Y, Yao X, Ouyang S, et al. Assessment of renal pathophysiological processes and protective effect of quercetin on contrast-induced acute kidney injury in type 1 diabetic mice using diffusion tensor imaging. Redox Rep. 2024;29:2398380. 10.1080/13510002.2024.2398380
- Guo X, Wu W, Ran Q, Wang L, Li Y, et al. Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology. J Ethnopharmacol. 2024;334:118524. 10.1016/j.jep.2024.118524
- Pei C, Yu J, Wang G, Jia YR, Shi X, et al. Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology. Biomed Chromatogr. 2024;38:e5893. 10.1002/bmc.5893
- Zhou F, Guo YX, Gao R, Ji XY, Tang YX, et al. Quercetin regulates dendritic cell activation by targeting STAT4 in the treatment of experimental autoimmune encephalomyelitis. Toxicol Appl Pharmacol. 2024;488:116980. 10.1016/j.taap.2024.116980
- Hossein A, Firouzeh G, Zeinab K, Gholamreza D. Quercetin prevents kidney against diabetes mellitus (type 1) in rats by inhibiting TGF-β/apelin gene expression. Mol Biol Rep. 2024;51:677. 10.1007/s11033-024-09617-z
- Hou Y, Chen C, Li Z, Wu J, Lyu S, et al. Protective effect of quercetin against macrophage-mediated hepatocyte injury via anti-inflammation, anti-apoptosis and inhibition of ferroptosis. Autoimmunity. 2024;57:2350202. 10.1080/08916934.2024.2350202
- Li X, Wang X, Qu X, Shi N, Li Q, et al. Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis. Int J Nanomedicine. 2024;19:3259. 10.2147/IJN.S457004
- Chen J, Huang C, Li M. [ granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:465. 10.12122/j.issn.1673-4254.2024.03.07
- Khater SI, El-Emam MMA, Abdellatif H, Mostafa M, Khamis T, et al. Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA. Life Sci. 2024;344:122546. 10.1016/j.lfs.2024.122546
